The winner of this award was Elaine M. Leslie, PhD (on left) from the University of Alberta.

Dr. Leslie is an associate professor in the department of physiology at the University of Alberta. She received her PhD from Queen’s University in Ontario, Canada.

The current focus of her laboratory is to understand how MRPs and GSTs are involved in the detoxification of the human carcinogen arsenic. Understanding how arsenic is detoxified is extremely important because millions of people world-wide are exposed to unacceptable levels of arsenic in drinking water.  Her laboratory uses recombinant human proteins and primary human cell models to identify and characterize arsenic biotransformation and transport pathways. The long-term goal of this research is to understand how genetic variation in human MRPs and GSTs influence the inter-individual susceptibility to arsenic-induced carcinogenesis.  She believes that ultimately these results will lead to the development of strategies to prevent and treat arsenic-induced carcinogenicity and toxicity.

Dr. Leslie has made important research contributions in four areas:

1) the role of transport proteins in tissue defense

2) arsenic transport by human MRP1 and MRP2

3) establishment of the physiological and toxicological relevance of the sandwich cultured hepatocyte (SCH) model and

4) hepatobiliary disposition of arsenic.